1. Vanadate protects irradiated mice from dying of either gastrointestinal or hematopoietic syndrome.
Vanadate protects irradiated mice from dying of either gastrointestinal or hematopoietic syndrome. A, 30-d survival tests of ICR mice after 8 or 12 Gy of TBI. Ten mice were used in each experimental subgroup, except for the subgroups of 8 Gy TBI alone (6 mice) and 12 Gy TBI alone (3 mice). P, comparison between the vanadate-treated and the cPFTα-treated subgroups (Student's t test). B and C, radioprotective efficacies of vanadate and cPFTα in H&E-stained sections of target tissues. The femurs were observed 7 d after 8 Gy TBI (B, ×300 magnification), and the intestine was observed 4 d after 12 Gy TBI (C, ×150 magnification).
Akinori Morita et al. Cancer Res 2010;70:
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