1. Southern California Clinical and Translational Science Institute The SC CTSI
Thomas A. Buchanan, MD
Founding Director
Navigating the University

2. BACKGROUND: CTSAs and SC CTSI
Clinical and Translational Science Awards (CTSAs)
Large infrastructure and training grants awarded to ~60 universities across the U.S.
The Southern California Clinical and Translational Science Institute (SC CTSI)
USC and CHLA’s institute to support clinical and translational science
Funded by a CTSA and local institutional support

3. Southern California CTSI at a Glance
Overarching Theme: DIVERSITY
Communities: diverse communities of LA
Clinical Settings: Keck, CHLA, LAC DHS
Academic Disciplines: across USC
Scientific Focus: T2-T4 Research
Setting: Partners: USC, CHLA, LA County DHS
Clinical Trials
Health Services
Community
Training

4. INTERNAL ADVISORY BOARD
People and Programs
SC CTSI
USC Provost
Elizabeth Graddy
INTERNAL ADVISORY BOARD
DIRECTORS TEAM
Institute Director
Thomas Buchanan
Institute Co-Director
Michele Kipke
EXTERNAL ADVISORY COMMITTEE
Operations & Finance
Quinnie Le
Programmatic Development
Allison Orechwa
Evaluation & Improvement
Katrina Kubicek
EXECUTIVE TEAM
Clinical Research Support
April Armstrong
John Wood
Community Engagement
Michele Kipke
Research Development
Sarah Hamm-Alvarez
Workforce Development
Cecilia Patino-Sutton
Steven Siegel
Biostatistics
Wendy Mack
Regulatory Support
Eunjoo Pacifici
Clinical Research Informatics
Daniella Meeker
Juan Espinoza
Implementation and Health Delivery Science
Amy Towfighi. MD

5. SC CTSI Resources and Services
CONSULTATIONS
Biostatistics
Community-Engaged Research
Digital Scholarship
Human Studies and Trials
Managing Data in REDCap
Research Ethics
Translational Research Team Building
CLINICAL RESEARCH SUPPORT
Navigator
Study Design
Recruitment
Study Coordinators
Regulatory Support
Budget and Coverage Analysis
Scientific Review
Voucher Program
Clinical Trials Units
CLINICAL RESEARCH INFORMATICS
Clinical Data Services
Clinical Trial Management System (CTMS)
Clinical Research Data Warehouse (DEWARS)
Local Study Participant Discovery Tool (i2b2)
Los Angeles Data Resource (LADR)
National Study Participant Discovery Tool
Data Management Tool (REDCap)
TRAINING AND EDUCATION
Training Video Library
Institutional Career Development Program (KL2)
Digital Scholar Program
TEAM BUILDING AND FUNDING
Pilot Awards
Team Building Vouchers
Team Building Toolkit
COMMUNITY ENGAGEMENT
Community-Engaged Research
Services for Researchers
Services for Community Members
Our Partners
SEARCH TOOLS
Clinical Studies Directory
Research Training Finder
Research Expert Finder (PROFILES)

6. Clinical Research Support (CRS): Research Services
Biostatistics and data management support
Study coordinators
Recruitment support
Budget assistance for IITs
Multi-site study planning and conduct
Regulatory support (IND/IDEs, auditing, monitoring)
Clinical Trials Unit (medium-to-high complexity studies)
Above services available at USC and CHLA*
Director (USC):
April Armstrong, MD, MPH
Director (CHLA):
John Wood, MD, PhD
Contact: Nicki Karimipour, PhD (USC)
usc.edu
Contact: Shannen Nelson, RN MSN (CHLA)
Analogous office at CHLA with similar services
Recharge model associated with some of these services is included in Supplemental Slides at the end
*Availability of services may vary between USC and CHLA CRS offices
Contact: Wendy Mack, PhD (USC)
Contact: Ji Hoon Ryoo, PhD,
Contact: Shannen Nelson, RN MSN (CHLA)

7. SC CTSI Study Navigation Tool
An e-tool to help you determine where to submit your clinical research study at USC
contracting offices,
review committees, ancillary services.
You answer drop-down questions
The tool provides primary units and systems you need to interact to activate a clinical study.
sc-ctsi.org/resources/new-study-navigation-tool

8. Patient Data Resources
Sample Size Planning / Feasibility Assessment (i2b2)
Counts of patients with specific characteristics
Self serve, no IRB approval required
Chart Screening and Recruitment
Chart access and/or patient contact information
Requires IRB approval (request is imbedded in IRB iStar application)
Health Economics, Data Mining, and Outcomes Research
de-identified data or limited data sets for retrospective analysis
Request imbedded in the IRB iStar application
Data provided in HIPAA compliant cloud environment
Informatics Director
Daniella Meeker, PhD
USC
Informatics Co-Director
Juan Espinoza, MD
CHLA

9. USC Health Science Profiles
Who publishes in a field
Profiles of Researchers

10. Clinical Studies Directory of USC
clinicaltrials.keckmedicine.org
Free, participant-friendly public landing page for studies
Allows interested participants to send an to a study coordinator
Can be linked to social media for digital recruitment

11. Mentored Career Development (KL2) Program
3-Year Mentored Career Development Program for junior faculty members who are clinically trained and wish to pursue a career in clinical and translational research
Four scholars per year selected by peer review of application and interview
Training includes course work, seminars and workshops, directed research, mentoring
Scholar’s receive
Salary support up to $90,000 plus fringe for a minimum of 75% effort (minimum of 50% for surgical specialties upon NIH approval).
Tuition/research/travel costs of up to $25,000  annually for three years:
Scholars academic unit pays one year, CTSA and Provost pay two years
Graduates (n=24) have 606 publications and $45M in extramural funding
Steve Siegel
MD, PhD
Cecilia Patino-Sutton MD, MPH
Contact: Jeanne Dzekov-McKean

12. Education and Training Dozens of courses, lectures, workshops
Highlights
Intro to Clinical Translational Research 3-course series
Research in Diverse Populations - short course
Regulatory Science workshops
Team Science workshops
Career Development seminars
REDCap (data acquisition and management too) workshops
One-on-one R01 application counseling
Online training finder
Visit our online library

13. Community Engagement
Advice and assistance for connecting with diverse, hard-to-reach populations
Facilitate academic-community partnerships; toolkits
Integration of community health workers – promotoras
Community-engaged research projects
Virtual navigator
Research Ambassadors program
Los Angeles Community Engagement Research Core
Hollywood Health & Society
Michele Kipke
PhD
Katrina Kubicek
PhD
Educating the community about research opportunities
Leveraging academic and community partnerships
Community Advisory Boards
Toolkits and support in creating a CAB to integrate community perspective throughout the research study
CE research:
Autism Disparity Program
LA-CERC: promoting community engaged research in the LA community
Hollywood Health and Society: provide entertainment industry with accurate info about health and hope to integrate compelling and realistic storylines about clinical research into popular TV programs
Contact: Mayra Rubio-Diaz

14. Research Development
Pilot funding and voucher programs to support multidisciplinary research teams
Promote, catalyze and support collaborative cross- disciplinary teams and projects
Education & training: Seminars, workshops (i.e. grant writing)
Grant application pre-review
Consultations
Director: Sara Hamm-Alvarez, PhD
Provide pilot funds to catalyze multidisciplinary teams to conduct innovative research projects that test the feasibility of novel technologies, methodologies and approaches to address challenges in clinical research and health problems of our diverse communities.
TEAM SCIENCE OBJECTIVES
Promote, catalyze and support collaborative cross-disciplinary teams and projects
Provide education and training to expand workforce capabilities in team science
Continue to foster changes in the academic environment to ensure appropriate recognition and reward of research team members
Contact: Juli Wu, PhD
Aileen Dinkjian, MPH
usc.edu

15. SC CTSI Funding Opportunities
$40,000 pilot grants (~10 per year)
Clinical or community research projects
Methods to improve clinical research methods and processes
Next application due date October 7, 2019
$75,000 implementation science grants (1 per year)
Implementation science projects in LA County Health System
FY20 Cycle Announcement coming soon
Small Grants and Vouchers
$3,000 team building grants (up to per year available)
$3,000 clinical research vouchers (~20 per year available)
Continuous submissions

16. Questions?

17. Questions?