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Early biomechanical changes in lower extremity vein grafts—distinct temporal phases of remodeling and wall stiffness  Christopher D. Owens, MD, Nicole.

Published byEliška Sedláková Modified over 5 years ago

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Presentation on theme: "Early biomechanical changes in lower extremity vein grafts—distinct temporal phases of remodeling and wall stiffness  Christopher D. Owens, MD, Nicole."— Presentation transcript:

1 Early biomechanical changes in lower extremity vein grafts—distinct temporal phases of remodeling and wall stiffness  Christopher D. Owens, MD, Nicole Wake, BS, Jeffrey G. Jacot, PhD, Marie Gerhard-Herman, MD, Peter Gaccione, MA, Michael Belkin, MD, Mark A. Creager, MD, Michael S. Conte, MD  Journal of Vascular Surgery  Volume 44, Issue 4, Pages (October 2006) DOI: /j.jvs Copyright © 2006 The Society for Vascular Surgery Terms and Conditions

2 Fig 1 A, Mean index segment lumen diameter changes of the entire population, demonstrating early outward remodeling most pronounced between 0 and 1 month, P = B, Scatter plot demonstrating mean and range of remodeling of graft configurations composed of greater saphenous veins in the 0-1 month and 1-3 month time interval. Data shown are for individual grafts with measurements at both of the indicated time points. All values are presented as mean ± SEM. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2006 The Society for Vascular Surgery Terms and Conditions

3 Fig 2 Great saphenous vein and arm vein index segments remodel in a similar fashion during the first month after bypass grafting. However, they diverge markedly between 1 and 6 months, P < All values are presented as the mean index segment lumen diameter ± SEM. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2006 The Society for Vascular Surgery Terms and Conditions

4 Fig 3 Early outward remodeling of the index segment is positively correlated with initial vein graft shear stress (r = .54, P = .03). Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2006 The Society for Vascular Surgery Terms and Conditions

5 Fig 4 The overall population of grafts showed an increase in wall stiffness (P = .014) during the first 6 months after bypass graft, with the major change observed between 1 and 3 months. Graphed values are presented as the mean ± SEM. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2006 The Society for Vascular Surgery Terms and Conditions

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