Presentation is loading. Please wait.

Presentation is loading. Please wait.

Reduced klotho expression in pancreatic cancer.

Published byEngin Meric Modified over 5 years ago

Similar presentations

Presentation on theme: "Reduced klotho expression in pancreatic cancer."— Presentation transcript:

1 Reduced klotho expression in pancreatic cancer.
Reduced klotho expression in pancreatic cancer. A, immunohistochemistry staining of klotho in normal pancreatic tissues, left: ×400 magnification, and zoom-in ×2.5, right, showing high klotho expression. B, adenocarcinoma (×400 magnification, left and ×1,000 magnification, right), showing very low expression of klotho. C and D, klotho mRNA levels were determined by quantitative RT-PCR in (C) pancreatic cancer cell lines relative to the expression in normal pancreatic tissue and (D) pancreatic adenocarcinoma clinical samples (T) and adjacent normal tissue (N). Lilach Abramovitz et al. Clin Cancer Res 2011;17: ©2011 by American Association for Cancer Research

Download ppt "Reduced klotho expression in pancreatic cancer."

Similar presentations

Glioma-derived soluble factor(s) enhance IL-10 signaling.

Glioma-derived soluble factor(s) enhance IL-10 signaling.
IL-1β stimulates CXCL5 and CXCL8 gene expression and protein secretion in A549 cells in a time- and dose-dependent manner. IL-1β stimulates CXCL5 and CXCL8.

IL-1β stimulates CXCL5 and CXCL8 gene expression and protein secretion in A549 cells in a time- and dose-dependent manner. IL-1β stimulates CXCL5 and CXCL8.
25(OH)D and 1,25(OH)2D perfusion treatment effect on cancer-related markers: IF stains illustrating expression levels for Ki-67 (A), cyclin D1 (B), ErbB-2.

25(OH)D and 1,25(OH)2D perfusion treatment effect on cancer-related markers: IF stains illustrating expression levels for Ki-67 (A), cyclin D1 (B), ErbB-2.
High-throughput analysis of informative CpG sites for the four studied tumor suppressor genes (A-D). High-throughput analysis of informative CpG sites.

High-throughput analysis of informative CpG sites for the four studied tumor suppressor genes (A-D). High-throughput analysis of informative CpG sites.
Quantitative PCR of CRTAC1 (white columns) and WASF1 (black columns) loci in germ line DNA (A), glomus tumor no. 1 (B), and glomus tumor no. 3 (C) from.

Quantitative PCR of CRTAC1 (white columns) and WASF1 (black columns) loci in germ line DNA (A), glomus tumor no. 1 (B), and glomus tumor no. 3 (C) from.
mRNA level as % relative to

mRNA level as % relative to
Fold Change of hsa-miR-3687 (T/N)(log2)

Fold Change of hsa-miR-3687 (T/N)(log2)
Quantitative RT-PCR results of relative gene expression normalized to wild-type (WT) expression levels for the LjMYB14 transgene (A) and genes specific.

Quantitative RT-PCR results of relative gene expression normalized to wild-type (WT) expression levels for the LjMYB14 transgene (A) and genes specific.
Increase in beige/brown adipocyte characteristics in the xenografts from additional breast cancer cell lines. Increase in beige/brown adipocyte characteristics.

Increase in beige/brown adipocyte characteristics in the xenografts from additional breast cancer cell lines. Increase in beige/brown adipocyte characteristics.
Collagen-dependent phosphorylation of eIF4E in PDAC cells.

Collagen-dependent phosphorylation of eIF4E in PDAC cells.
Programmed cell death ligand-1 (PD-L1) immunohistochemistry for pulmonary adenocarcinoma tissues. Programmed cell death ligand-1 (PD-L1) immunohistochemistry.

Programmed cell death ligand-1 (PD-L1) immunohistochemistry for pulmonary adenocarcinoma tissues. Programmed cell death ligand-1 (PD-L1) immunohistochemistry.
NICD1 immunohistochemical staining in normal and tumor tissue.

NICD1 immunohistochemical staining in normal and tumor tissue.
Expression of the neural stem cell–specific marker nestin in a distinct cell population within pancreatic islets. Expression of the neural stem cell–specific.

Expression of the neural stem cell–specific marker nestin in a distinct cell population within pancreatic islets. Expression of the neural stem cell–specific.
QSOX1 is highly expressed in tumor cell lines but is not expressed in adjacent normal cells. QSOX1 is highly expressed in tumor cell lines but is not expressed.

QSOX1 is highly expressed in tumor cell lines but is not expressed in adjacent normal cells. QSOX1 is highly expressed in tumor cell lines but is not expressed.
SIRT1 is downregulated in human gastric cancer (GC).

SIRT1 is downregulated in human gastric cancer (GC).
Human and mouse islets express MCH and MCHR1.

Human and mouse islets express MCH and MCHR1.
Aberrant regulation of HDAC2 and its association with malignant proliferation of human gastric cancer. Aberrant regulation of HDAC2 and its association.

Aberrant regulation of HDAC2 and its association with malignant proliferation of human gastric cancer. Aberrant regulation of HDAC2 and its association.
TFAP2A is highly expressed in nasopharyngeal carcinoma cells and tumor tissues. TFAP2A is highly expressed in nasopharyngeal carcinoma cells and tumor.

TFAP2A is highly expressed in nasopharyngeal carcinoma cells and tumor tissues. TFAP2A is highly expressed in nasopharyngeal carcinoma cells and tumor.
Activating mutation of Ras is associated with CDCP1 expression in NSCLC. A, NSCLC cell lines with Ras + B-Raf mutations and wild-type Ras were examined.

Activating mutation of Ras is associated with CDCP1 expression in NSCLC. A, NSCLC cell lines with Ras + B-Raf mutations and wild-type Ras were examined.
Immunohistochemical analyses of SHH expression levels in nonmalignant prostate and adenocarcinoma tissues. Immunohistochemical analyses of SHH expression.

Immunohistochemical analyses of SHH expression levels in nonmalignant prostate and adenocarcinoma tissues. Immunohistochemical analyses of SHH expression.

Similar presentations

Ads by Google