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CREBBP inactivation disables acetylation and results in unopposed deacetylation by the BCL6/SMRT/HDAC3 complex, which disrupts enhancer activity in B cells.

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Presentation on theme: "CREBBP inactivation disables acetylation and results in unopposed deacetylation by the BCL6/SMRT/HDAC3 complex, which disrupts enhancer activity in B cells."— Presentation transcript:

1 CREBBP inactivation disables acetylation and results in unopposed deacetylation by the BCL6/SMRT/HDAC3 complex, which disrupts enhancer activity in B cells. CREBBP inactivation disables acetylation and results in unopposed deacetylation by the BCL6/SMRT/HDAC3 complex, which disrupts enhancer activity in B cells. Ac, acetyl groups; HDAC3, histone deacetylase 3; NCoR, nuclear receptor corepressor; SMRT, silencing mediator of retinoic acid and thyroid hormone receptor. Uta E. Höpken Cancer Discov 2017;7:14-16 ©2017 by American Association for Cancer Research

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