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Fig. 6. Confocal image series at 10-μm intervals through the full retinal thickness at P48 in WT and vldlr-null mice. Confocal image series at 10-μm intervals.

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Presentation on theme: "Fig. 6. Confocal image series at 10-μm intervals through the full retinal thickness at P48 in WT and vldlr-null mice. Confocal image series at 10-μm intervals."— Presentation transcript:

1 Fig. 6. Confocal image series at 10-μm intervals through the full retinal thickness at P48 in WT and vldlr-null mice. Confocal image series at 10-μm intervals through the full retinal thickness at P48 in WT and vldlr-null mice. (A and B) Isolectin IB4–stained vasculature of whole-mount retinas viewed through the entire 200-μm thickness (microscope objective 10×, 21 superimposed confocal slices) of P48 WT mice and vldlr-null (KO) mice treated with control D(CAPAC) peptide or Vasotide. In (A), these 3D vascular images are viewed from the retinal inner surface (“z” direction), and in (B), in a cross-sectional view (“y” direction). Formations of abnormal vascular tufts are indicated by yellow arrowheads in (A) and yellow arrows in (B). In the WT mouse retina, a representative H&E-stained retinal image has been superimposed to show the relationship between retinal layers and the vasculature. (C) A full set of vascular images of the vldlr-null mouse retina treated with control D(CAPAC) peptide. (D) Comparable images from a vldlr-null mouse retina treated with Vasotide. (E) Graphs of blood vessel concentrations at six treatment ages. Richard L. Sidman et al., Sci Transl Med 2015;7:309ra165 Copyright © 2015, American Association for the Advancement of Science

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