1. Outline of study protocol.
Outline of study protocol. On the preceding evening of each study visit, either 50 mg vildagliptin (VILD) or a placebo (PLBO) tablet was given with a standardized meal. On each study day, at t = −90 min, either 50 mg vildagliptin or a placebo tablet was given. At t = −30 min, a 250-mL preload drink containing either 25 g whey or control flavoring (CTRL) was consumed, followed by a 13C-octanoate–labeled mashed potato meal (at t = 0–5 min). Venous blood was obtained at frequent intervals during the study for measurement of plasma glucose, insulin, glucagon, GLP-1, and GIP. Gastric emptying was determined by breath test.
Tongzhi Wu et al. Dia Care 2016;39:
©2016 by American Diabetes Association