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Autophagy Devours the Nuclear Lamina to Thwart Oncogenic Stress

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Presentation on theme: "Autophagy Devours the Nuclear Lamina to Thwart Oncogenic Stress"— Presentation transcript:

1 Autophagy Devours the Nuclear Lamina to Thwart Oncogenic Stress
Andrew M. Leidal, Jayanta Debnath  Developmental Cell  Volume 35, Issue 5, Pages (December 2015) DOI: /j.devcel Copyright © 2015 Elsevier Inc. Terms and Conditions

2 Figure 1 Autophagy-Dependent Degradation of the Nuclear Lamina
In proliferating cells, a nuclear pool of the autophagy protein MAP1LC3 (LC3) interacts with nuclear lamina protein lamin B1 at heterochromatin regions called lamin-associated domains (LADs). Upon oncogenic insult (i.e., short telomeres, DNA damage, constitutive RAS activation), nuclear LC3 mobilizes chromatin-associated lamin B1 into the cytoplasm for degradation via autophagy, which reinforces senescence. Developmental Cell  , DOI: ( /j.devcel ) Copyright © 2015 Elsevier Inc. Terms and Conditions

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