1. Volume 3, Issue 1, Pages 31-39 (January 2016)
Comparative evaluation of quetiapine plus lamotrigine combination versus quetiapine monotherapy (and folic acid versus placebo) in bipolar depression (CEQUEL): a 2 × 2 factorial randomised trial 
Prof John R Geddes, MD, Alexandra Gardiner, BSc, Jennifer Rendell, DPhil, Merryn Voysey, MBiostat, Elizabeth Tunbridge, DPhil, Christopher Hinds, DPhil, Ly-Mee Yu, MSc, Jane Hainsworth, BSc, Mary-Jane Attenburrow, MRCPsych, Prof Judit Simon, DPhil, Prof Guy M Goodwin, FMedSci, Prof Paul J Harrison, DM 
The Lancet Psychiatry 
Volume 3, Issue 1, Pages (January 2016)
DOI: /S (15)
Copyright © 2016 Geddes et al. Open Access article distributed under the terms of CC BY Terms and Conditions

2. Figure 1
Trial profile
The Lancet Psychiatry 2016 3, 31-39DOI: ( /S (15) )
Copyright © 2016 Geddes et al. Open Access article distributed under the terms of CC BY Terms and Conditions

3. Figure 2
Observed and estimated mean QIDS-SR16 scores at key timepoints by comparisons for lamotrigine (A) and folic acid (B)
Error bars show 95% CI. QIDS-SR16=Quick Inventory of Depressive Symptomatology—self report version.
The Lancet Psychiatry 2016 3, 31-39DOI: ( /S (15) )
Copyright © 2016 Geddes et al. Open Access article distributed under the terms of CC BY Terms and Conditions

4. Figure 3
Forest plot showing within-group model estimates by timepoint and folic acid group
QIDS-SR16=Quick Inventory of Depressive Symptomatology—self report version.
The Lancet Psychiatry 2016 3, 31-39DOI: ( /S (15) )
Copyright © 2016 Geddes et al. Open Access article distributed under the terms of CC BY Terms and Conditions