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EGFR signaling regulates transcription of PDGFRβ gene.

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Presentation on theme: "EGFR signaling regulates transcription of PDGFRβ gene."— Presentation transcript:

1 EGFR signaling regulates transcription of PDGFRβ gene.
EGFR signaling regulates transcription of PDGFRβ gene. A, time course of PDGFRβ primary transcript and mRNA expression in U87-EGFRvIII cells treated with erlotinib (5 μmol/L) or vehicle for up to 32 hours. B, determination of PDGFRβ mRNA expression in response to erlotinib treatment or media washout over 60 hours. C, luciferase assay comparing PDGFRβ promoter activity in U87-EGFRvIII cells transfected with scrambled siRNA to siRNA against Raptor or EGFRvIII. D, ChIP of RNA polymerase II at the promoter or exon 1 of PDGFRβ gene following treatment with vehicle or rapamycin (5 nmol/L) for 24 hours. **, P < 0.01; ***, P < n.s., no statistical significance. David Akhavan et al. Cancer Discovery 2013;3: ©2013 by American Association for Cancer Research

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