1. Schematic representation of the sequelae of overweight/obesity and type 2 diabetes with regard to neuropathy and GERD. A positive feedback exists among neuropathy, GERD, management with acid-suppressing medications, and vitamin B12 deficiency.
Schematic representation of the sequelae of overweight/obesity and type 2 diabetes with regard to neuropathy and GERD. A positive feedback exists among neuropathy, GERD, management with acid-suppressing medications, and vitamin B12 deficiency. The figure illustrates an additive effect of concomitant metformin and acid-suppression therapy leading to neuropathy via compounded vitamin B12 depletion.
Matthew J. Zdilla Clin Diabetes 2015;33:90-95
©2015 by American Diabetes Association