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Rikke F. Vestergaard, MD, PhD, Annemarie Brüel, MD, DMS, Jesper S

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Presentation on theme: "Rikke F. Vestergaard, MD, PhD, Annemarie Brüel, MD, DMS, Jesper S"— Presentation transcript:

1 The Influence of Hemostatic Agents on Bone Healing After Sternotomy in a Porcine Model 
Rikke F. Vestergaard, MD, PhD, Annemarie Brüel, MD, DMS, Jesper S. Thomsen, PhD, DMS, Ellen M. Hauge, MD, PhD, Kjeld Søballe, MD, DMS, J. Michael Hasenkam, MD, DMS  The Annals of Thoracic Surgery  Volume 99, Issue 3, Pages (March 2015) DOI: /j.athoracsur Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

2 Fig 1 Schematic of set-up used for mechanical testing. The bone specimen is placed under a pressure point on a plate with a fixed gap size. Pressure is increased until bone fracture occurs. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

3 Fig 2 Volume fraction of granulation tissue distributed by treatment groups. Mean is indicated by the horizontal line. Statistically significant difference between the BW group and the WSW group (p < 0.001) indicated with ˆ and the control group (p < 0.001) indicated with*. (BW = bone wax; C = control; WSW = water-soluble wax.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

4 Fig 3 Mechanical stiffness (dF/dx) of the first segments. The mechanical stiffness of the sternums in the BW group is generally less than the other two groups. However, only the difference between the BW and control group was statistically significant (p<0.05) indicated with*. The mean value is indicated by a horizontal line. However, there are outliers especially in the control and BW groups, that significantly influence the results. (BW = bone wax; C = control; WSW = water-soluble wax.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

5 Fig 4 Fracture strength (Fmax) of the first segments. The fracture strength of the sternums in the BW group is generally lower than in the other two groups. However, the only statistically significant difference is found between the BW and the control groups (p = 0.043) indicated with*. Mean = horizontal line. Significant outliers are seen in the BW group. (BW = bone wax; C = control; WSW = water-soluble wax.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

6 Fig 5 Mechanical stiffness (dF/dx) of the second segments. There were no significant differences in mechanical stiffness between the groups. Mean = horizontal line. (BW = bone wax; C = control; WSW = water-soluble wax.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

7 Fig 6 Fracture strength (Fmax) of the second segments. No significant differences in fracture strength were seen. Mean = horizontal line. (BW = bone wax; C = control; WSW = water-soluble wax.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions


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