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DNA damage in patients with untreated cancer as measured by the sperm chromatin structure assay  Hiroshi Kobayashi, M.D., Kjersten Larson, M.S., Rakesh.

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Presentation on theme: "DNA damage in patients with untreated cancer as measured by the sperm chromatin structure assay  Hiroshi Kobayashi, M.D., Kjersten Larson, M.S., Rakesh."— Presentation transcript:

1 DNA damage in patients with untreated cancer as measured by the sperm chromatin structure assay 
Hiroshi Kobayashi, M.D., Kjersten Larson, M.S., Rakesh K Sharma, Ph.D., David R Nelson, M.S., Donald P Evenson, Ph.D., Hiroshi Toma, M.D., Anthony J Thomas, M.D., Ashok Agarwal, Ph.D.  Fertility and Sterility  Volume 75, Issue 3, Pages (March 2001) DOI: /S (00)

2 Figure 1 Representative sperm chromatin structure assay data from (A) fertile donor, (B and C) testicular cancer, (D) non–Hodgkin’s lymphoma patients. Cytograms in the left column show green versus red fluorescence of 7,000 spermatozoa. Cytograms of total fluorescence versus alphat are in the middle column. Alphat histograms with cells outside main population (COMPαt regions) are shown in the right column. Note the increased DNA denaturation represented by the increased red fluorescence and COMPαt in one of the two testicular patients (B) and in the non–Hodgkin’s lymphoma patient (D). The region for high green fluorescence is indicated in the upper left-hand cytogram. Kobayashi. DNA damage in untreated cancer patients. Fertil Steril 2001. Fertility and Sterility  , DOI: ( /S (00) )


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