Presentation is loading. Please wait.

Presentation is loading. Please wait.

Prostaglandin E2 attenuates the host antitumor immunity to promote the HFD-induced HCC development. Prostaglandin E2 attenuates the host antitumor immunity.

Published byWidyawati Cahyadi Modified over 5 years ago

Similar presentations

Presentation on theme: "Prostaglandin E2 attenuates the host antitumor immunity to promote the HFD-induced HCC development. Prostaglandin E2 attenuates the host antitumor immunity."— Presentation transcript:

1 Prostaglandin E2 attenuates the host antitumor immunity to promote the HFD-induced HCC development.
Prostaglandin E2 attenuates the host antitumor immunity to promote the HFD-induced HCC development. A, Schematic representation of the experimental design. Immune cells isolated from DMBA-treated, HFD-fed livers were incubated with 1 μmol/L PGD2, PGE2, or PGF2α in the presence of 10 μg/mL LTA for 24 hours and culture supernatants were harvested to determine cytokine production. Veh, vehicle (DMSO). B, IFNγ, TNFα, and IL5 levels in culture supernatant measured by multiplex assay. Data, means ± SD (n = 3). NS, not significant; *, P < 0.05; **, P < C, qPCR analysis of relative mRNA levels of Ptger1, Ptger2, Ptger3, and Ptger4 in nontumor (NT) or tumor (T) region of mouse livers. Data of three individual mice were shown as means ±SD. NS, not significant; *, P < D, means DMBA-treated. D, qPCR analysis of relative mRNA levels of Ptger4 in each cell type isolated from the liver. Data, means ± SD (n = 3). Tze Mun Loo et al. Cancer Discov 2017;7: ©2017 by American Association for Cancer Research

Download ppt "Prostaglandin E2 attenuates the host antitumor immunity to promote the HFD-induced HCC development. Prostaglandin E2 attenuates the host antitumor immunity."

Similar presentations

TNFR1 and TNFR2 are expressed on native human ASM but activation of TNFR1 mediates ICAM-1 expression in human ASM cells. TNFR1 and TNFR2 are expressed.

TNFR1 and TNFR2 are expressed on native human ASM but activation of TNFR1 mediates ICAM-1 expression in human ASM cells. TNFR1 and TNFR2 are expressed.
Cytokine-induced rapid ICAM-1 expression on human ASM promotes adhesion of activated T lymphocytes. Cytokine-induced rapid ICAM-1 expression on human ASM.

Cytokine-induced rapid ICAM-1 expression on human ASM promotes adhesion of activated T lymphocytes. Cytokine-induced rapid ICAM-1 expression on human ASM.
Effects of MAX reconstitution and of BRG1 depletion in lung cancer cells. Effects of MAX reconstitution and of BRG1 depletion in lung cancer cells. A,

Effects of MAX reconstitution and of BRG1 depletion in lung cancer cells. Effects of MAX reconstitution and of BRG1 depletion in lung cancer cells. A,
Expression of immune checkpoint molecules on leukocytes and tumor cells at baseline and in response to selinexor. Expression of immune checkpoint molecules.

Expression of immune checkpoint molecules on leukocytes and tumor cells at baseline and in response to selinexor. Expression of immune checkpoint molecules.
Effects of BRG1 depletion in the proliferation of lung cancer cells with amplification at the MYC family of genes and in MAX-deficient cells, after reconstitution.

Effects of BRG1 depletion in the proliferation of lung cancer cells with amplification at the MYC family of genes and in MAX-deficient cells, after reconstitution.
IFNα, but not IFNλ, treatment induces cytokine secretion from human immune cells IFNα, but not IFNλ, treatment induces cytokine secretion from human immune.

IFNα, but not IFNλ, treatment induces cytokine secretion from human immune cells IFNα, but not IFNλ, treatment induces cytokine secretion from human immune.
Enhancement of the host immune responses in cutaneous T-cell lymphoma by CpG oligodeoxynucleotides and IL-15 by Maria Wysocka, Bernice M. Benoit, Sarah.

Enhancement of the host immune responses in cutaneous T-cell lymphoma by CpG oligodeoxynucleotides and IL-15 by Maria Wysocka, Bernice M. Benoit, Sarah.
BV6 increases tumor burden in bone.

BV6 increases tumor burden in bone.
Tumor development of poorly immunogenic LLC and B16F10 cells modified to produce GM-CSF was markedly inhibited. Tumor development of poorly immunogenic.

Tumor development of poorly immunogenic LLC and B16F10 cells modified to produce GM-CSF was markedly inhibited. Tumor development of poorly immunogenic.
The PI3K–Akt pathway is essential for the in vivo maintenance of murine Tregs. The PI3K–Akt pathway is essential for the in vivo maintenance of murine.

The PI3K–Akt pathway is essential for the in vivo maintenance of murine Tregs. The PI3K–Akt pathway is essential for the in vivo maintenance of murine.
IL-6 is dispensable for the suppressive activity of MDSC on primary CD4+ T-cell activation. IL-6 is dispensable for the suppressive activity of MDSC on.

IL-6 is dispensable for the suppressive activity of MDSC on primary CD4+ T-cell activation. IL-6 is dispensable for the suppressive activity of MDSC on.
Peritumoral injections of poly(I:C) induce type I IFN–dependent cytotoxic immunity and delay the growth of primary and transplanted Hgf-Cdk4R24C melanomas.

Peritumoral injections of poly(I:C) induce type I IFN–dependent cytotoxic immunity and delay the growth of primary and transplanted Hgf-Cdk4R24C melanomas.
Treatment with BLU9931 leads to tumor regression in the FGF19-amplified Hep 3B liver cancer model. Treatment with BLU9931 leads to tumor regression in.

Treatment with BLU9931 leads to tumor regression in the FGF19-amplified Hep 3B liver cancer model. Treatment with BLU9931 leads to tumor regression in.
The absence of ADCC by nivolumab in vitro.

The absence of ADCC by nivolumab in vitro.
Prostaglandin E2 suppresses allergic sensitization and lung inflammation by targeting the E prostanoid 2 receptor on T cells  Zbigniew Zasłona, PhD, Katsuhide.

Prostaglandin E2 suppresses allergic sensitization and lung inflammation by targeting the E prostanoid 2 receptor on T cells  Zbigniew Zasłona, PhD, Katsuhide.
Antitumor effect of local cancer immunotherapy treatment toward distant B16F10 tumors. Antitumor effect of local cancer immunotherapy treatment toward.

Antitumor effect of local cancer immunotherapy treatment toward distant B16F10 tumors. Antitumor effect of local cancer immunotherapy treatment toward.
COX-2–PGE2 signaling is required for MSC-induced increase in ALDHhigh CSC-enriched population and tumor initiation. COX-2–PGE2 signaling is required for.

COX-2–PGE2 signaling is required for MSC-induced increase in ALDHhigh CSC-enriched population and tumor initiation. COX-2–PGE2 signaling is required for.
A role for galectin-3 in promoting lung colonization in ST6GalNAc2-silenced cells. A role for galectin-3 in promoting lung colonization in ST6GalNAc2-silenced.

A role for galectin-3 in promoting lung colonization in ST6GalNAc2-silenced cells. A role for galectin-3 in promoting lung colonization in ST6GalNAc2-silenced.
Prostaglandin E2 suppresses allergic sensitization and lung inflammation by targeting the E prostanoid 2 receptor on T cells  Zbigniew Zasłona, PhD, Katsuhide.

Prostaglandin E2 suppresses allergic sensitization and lung inflammation by targeting the E prostanoid 2 receptor on T cells  Zbigniew Zasłona, PhD, Katsuhide.
High‐fat diet augments gut permeability, metabolic endotoxemia, and systemic inflammation High‐fat diet augments gut permeability, metabolic endotoxemia,

High‐fat diet augments gut permeability, metabolic endotoxemia, and systemic inflammation High‐fat diet augments gut permeability, metabolic endotoxemia,

Similar presentations

Ads by Google