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Volume 379, Issue 9835, Pages (June 2012)

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1 Volume 379, Issue 9835, Pages 2489-2499 (June 2012)
Invasive non-typhoidal salmonella disease: an emerging and neglected tropical disease in Africa  Nicholas A Feasey, FRCPath, Gordon Dougan, PhD, Robert A Kingsley, PhD, Robert S Heyderman, PhD, Dr Melita A Gordon, MD  The Lancet  Volume 379, Issue 9835, Pages (June 2012) DOI: /S (11) Copyright © 2012 Elsevier Ltd Terms and Conditions

2 Figure 1 Map of Africa showing results of a meta-analysis of studies investigating the cause of bloodstream infection in febrile adults and children in Africa Reproduced from Reddy and colleagues.3 BSI=bloodstream infection. The Lancet  , DOI: ( /S (11) ) Copyright © 2012 Elsevier Ltd Terms and Conditions

3 Figure 2 Clinical features of invasive non-typhoidal salmonella disease in adults and children in Africa The Lancet  , DOI: ( /S (11) ) Copyright © 2012 Elsevier Ltd Terms and Conditions

4 Figure 3 Features of host adaptation in salmonellae and effects on clinical syndrome in the host The Lancet  , DOI: ( /S (11) ) Copyright © 2012 Elsevier Ltd Terms and Conditions

5 Figure 4 Three key defects that contribute to the pathogenesis of invasive non-typhoidal salmonellae in HIV-positive people Arrows show routes of dissemination of salmonellae. The Lancet  , DOI: ( /S (11) ) Copyright © 2012 Elsevier Ltd Terms and Conditions

6 Figure 5 Radial phylogram showing the phylogenetic relations of Salmonella enterica var Typhimurium (S Typhimurium) sequence types (STs) The S Typhimurium sequence types (red or yellow circles) are rooted to Salmonella enterica var Typhi (S Typhi) (blue circle) and Salmonella enterica var Paratyphi A (S Paratyphi A) (green circle). Genetic distance is calculated as the number of single nucleotide polymorphisms per base and is indicated as a solid black line. The length of this line is proportional to the degree of genetic divergence. S Typhimurium sequence types from various worldwide locations outside sub-Saharan Africa (red) and from sub-Saharan AfrIca (yellow) are shown. The Lancet  , DOI: ( /S (11) ) Copyright © 2012 Elsevier Ltd Terms and Conditions


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