1. Understanding the Role of Disability in MS Management

2. Case Study 1

3. Disease Mechanisms Explaining Disability Worsening in Patient With NEDA

4. Potential Add-On to MS Treatment

5. Neurofilaments Biomarkers of Silent Disease Activity

6. Impact of Comorbidities on Disability Progression

7. Overlap of Common Perimenopausal and MS Symptoms

8. Clinical Course of MS

9. Case Study 2

10. ORATORIO Subgroup Analysis Upper limb function

11. ORATORIO Subgroup Analysis Results

12. ORATORIO-HAND Phase 3b Study Design

13. MS Length-Dependent Axonopathy Characteristics

14. Evidence for a Modifiable Disease Activity Component in PMS Trials

15. Therapeutic Window in Progressive MS

16. Potential Efficacy of DMT in Progressive MS

17. Case Study 3

18. MS Disease Stratification for Treatment

19. PCORI-Funded Study in MS

20. Treatment Strategies Escalation vs Induction

21. MSBase Registry

22. NEDADI

23. Strategies for Longitudinal Patient Monitoring FITRiMS

24. FitRIMS

25. Strategies for Longitudinal Patient Monitoring FLOODLIGHT

26. MS Brain Health Initiative

27. Conclusions

28. Abbreviations

29. Abbreviations (cont)

30. Abbreviations (cont)