1. Innate B Cells Tell ILC How It’s Done
Trang T.T. Nguyen, Nicole Baumgarth 
Immunity 
Volume 45, Issue 1, Pages 8-10 (July 2016)
DOI: /j.immuni
Copyright © 2016 Elsevier Inc. Terms and Conditions

2. Figure 1 Development and Activation of NKB
Bone marrow pro B cells give rise to CD122pos NKB precursors in an Id-2-dependent manner. Activation of splenic NKBP by infections with various intracellular pathogens such as Salmonella Typhimurium and Listeria monocytogenes causes rapid activation and differentiation to IL-12 and IL-18 producing CD122neg NKB cells. These cytokines in turn trigger IFN-γ production by ILC1, including NK cells, which leads to induction of Th1 T cell responses and control of the infection.
Immunity  , 8-10DOI: ( /j.immuni )
Copyright © 2016 Elsevier Inc. Terms and Conditions