1. Pharmacokinetic behavior of mycophenolate mofetil (MMF) after oral administration (see text for details).
Pharmacokinetic behavior of mycophenolate mofetil (MMF) after oral administration (see text for details). MMF is converted to mycophenolic acid (MPA) presystemically, and then is subsequently metabolized to its glucuronide (Glu) conjugates, MPAG and AcMPAG, by different isoforms of UDP glucuronidyl transferses (UGT) in the liver. Pathways of enterohepatic circulation of MPA via the glucuronide conjugate metabolites are shown.
Hyunyoung Jeong, and Bruce Kaplan CJASN 2007;2:
©2007 by American Society of Nephrology