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FANCD2 Hurdles the DNA Interstrand Crosslink

Published byΒαράκ Βλαβιανός Modified over 5 years ago

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Presentation on theme: "FANCD2 Hurdles the DNA Interstrand Crosslink"— Presentation transcript:

1 FANCD2 Hurdles the DNA Interstrand Crosslink
George-Lucian Moldovan, Alan D. D'Andrea  Cell  Volume 139, Issue 7, Pages (December 2009) DOI: /j.cell Copyright © 2009 Elsevier Inc. Terms and Conditions

2 Figure 1 FANCD2 Monoubiquitination in the Repair of Interstrand Crosslinks Crosslink repair is initiated by stalling of the two replication forks on either side of the interstrand crosslink (ICL). One of the forks subsequently moves to the crosslink site. By the time the fork reaches position −1, FANCD2 has been monoubiquitinated by the Fanconi Anemia (FA) core complex. Ubiquitinated FANCI-FANCD2 then promotes nucleolytic incisions and the unhooking of the crosslink, allowing bypass of the lesion by polymerases. Finally, homologous recombination concludes the repair reaction. Monoubiquitinated FANCD2 may directly activate nucleolytic processes (top inset), recruit translesion synthesis polymerases (bottom inset), or both. Cell  , DOI: ( /j.cell ) Copyright © 2009 Elsevier Inc. Terms and Conditions

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