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Striking the Right Balance: Cortical Modulation of the Subthalamic Nucleus-Globus Pallidus Circuit
Kevin J. Mastro, Aryn H. Gittis Neuron Volume 85, Issue 2, Pages (January 2015) DOI: /j.neuron Copyright © 2015 Elsevier Inc. Terms and Conditions
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Figure 1 Induction and Strengthening of GPe-STN Synapses by Cortically Driven hLTP Left: Cortical (M1) activation of NMDA channels causes influx of calcium and activation of CaMKII that induces two pathways: (1) synthesis and release of nitric oxide (NO), which activates a guanylate cyclase (GC)-protein kinase G (PKG) pathway, and (2) insertion of GABAAR in deficient or silent synapses. Right: Following stimulation, M1-STN synapses are strengthened by the insertion of AMPARs; GPe-STN synapses are strengthened by an increase in postsynaptic GABAARs as well as an increase in presynaptic release. Neuron , DOI: ( /j.neuron ) Copyright © 2015 Elsevier Inc. Terms and Conditions
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