Presentation is loading. Please wait.

Presentation is loading. Please wait.

EMT alters activation of AKT and serum-independent proliferation.

Published byAstrid Mathisen Modified over 5 years ago

Similar presentations

Presentation on theme: "EMT alters activation of AKT and serum-independent proliferation."— Presentation transcript:

1 EMT alters activation of AKT and serum-independent proliferation.
EMT alters activation of AKT and serum-independent proliferation. A, H358-TwistER– and H358-SnailER–expressing cells cultured over 15 days with 100 nmol/L 4-hydroxytamoxifen (4OHT). B, basal phosphorylation (p) of AKT (S473), AKT effectors, and extracellular signal-regulated kinase (ERK) in H358-TwistER and H358-SnailER cells before (NT) and after (4OHT) 14 days of 4OHT treatment with (10%) or without (SS, serum starved) serum overnight. C and D, proliferation of untreated (top) or 4OHT-pretreated (bottom) H358-TwistER and H358-SnailER cells in the presence (10%) or absence (SS) of serum. Error bars represent SD. Megan B. Salt et al. Cancer Discovery 2014;4: ©2014 by American Association for Cancer Research

Download ppt "EMT alters activation of AKT and serum-independent proliferation."

Similar presentations

Date of download: 6/22/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Hyaluronan and the Interaction Between CD44 and Epidermal.

Date of download: 6/22/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Hyaluronan and the Interaction Between CD44 and Epidermal.
PI 3-kinase inhibition has no effect on ANG II induced extracellular recognition kinase (ERK) 1/2 activation. PI 3-kinase inhibition has no effect on ANG.

PI 3-kinase inhibition has no effect on ANG II induced extracellular recognition kinase (ERK) 1/2 activation. PI 3-kinase inhibition has no effect on ANG.
Copyright © 2010 American Medical Association. All rights reserved.

Copyright © 2010 American Medical Association. All rights reserved.
From: IGF-1 Regulates the Extracellular Level of Active MMP-2 and Promotes Müller Glial Cell Motility Invest. Ophthalmol. Vis. Sci.. 2015;56(11):6948-6960.

From: IGF-1 Regulates the Extracellular Level of Active MMP-2 and Promotes Müller Glial Cell Motility Invest. Ophthalmol. Vis. Sci ;56(11):
HER2 mutations V777L, D769H, V842I, G309A induce gain-of-function over HER2 WT in MCF10A mammary epithelial cells. HER2 mutations V777L, D769H, V842I,

HER2 mutations V777L, D769H, V842I, G309A induce gain-of-function over HER2 WT in MCF10A mammary epithelial cells. HER2 mutations V777L, D769H, V842I,
Inhibition of PDGFR-β downstream signaling events by flavones.

Inhibition of PDGFR-β downstream signaling events by flavones.
Nicotine Induces Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor by α1 Nicotinic Acetylcholine Receptor–Mediated Activation in.

Nicotine Induces Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor by α1 Nicotinic Acetylcholine Receptor–Mediated Activation in.
The cyclolignan picropodophyllin attenuates intimal hyperplasia after rat carotid balloon injury by blocking insulin-like growth factor-1 receptor signaling 

The cyclolignan picropodophyllin attenuates intimal hyperplasia after rat carotid balloon injury by blocking insulin-like growth factor-1 receptor signaling 
Relationship between adhesion plaque formation, FAK/ERK signaling, and proliferation. Relationship between adhesion plaque formation, FAK/ERK signaling,

Relationship between adhesion plaque formation, FAK/ERK signaling, and proliferation. Relationship between adhesion plaque formation, FAK/ERK signaling,
by Xingwei Sui, Sanford B. Krantz, Min You, and Zhizhuang Zhao

by Xingwei Sui, Sanford B. Krantz, Min You, and Zhizhuang Zhao
Identification of a MEK2 mutation in a melanoma sample resistant to dabrafenib/trametinib. Identification of a MEK2 mutation in a melanoma sample resistant.

Identification of a MEK2 mutation in a melanoma sample resistant to dabrafenib/trametinib. Identification of a MEK2 mutation in a melanoma sample resistant.
Volume 67, Issue 6, Pages (June 2005)

Volume 67, Issue 6, Pages (June 2005)
Nicotine Induces Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor by α1 Nicotinic Acetylcholine Receptor–Mediated Activation in.

Nicotine Induces Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor by α1 Nicotinic Acetylcholine Receptor–Mediated Activation in.
PDK1 regulates PLK1 in vivo and in vitro.

PDK1 regulates PLK1 in vivo and in vitro.
Bortezomib sensitivity correlates with basal NF-κB activity in KP lung adenocarcinoma cell lines. Bortezomib sensitivity correlates with basal NF-κB activity.

Bortezomib sensitivity correlates with basal NF-κB activity in KP lung adenocarcinoma cell lines. Bortezomib sensitivity correlates with basal NF-κB activity.
NF1 downregulation activates MAPK pathway signaling.

NF1 downregulation activates MAPK pathway signaling.
nab-Paclitaxel targets the tumor epithelial cells.

nab-Paclitaxel targets the tumor epithelial cells.
The EGF receptor confers BRAF inhibitor resistance in BRAF-mutant melanoma cells. The EGF receptor confers BRAF inhibitor resistance in BRAF-mutant melanoma.

The EGF receptor confers BRAF inhibitor resistance in BRAF-mutant melanoma cells. The EGF receptor confers BRAF inhibitor resistance in BRAF-mutant melanoma.
The selective PI3K inhibitor A66 suppresses PIP3 accumulation, AKT phosphorylation at Thr308, and YAP/TAZ–regulated gene expression in PDAC cells. The.

The selective PI3K inhibitor A66 suppresses PIP3 accumulation, AKT phosphorylation at Thr308, and YAP/TAZ–regulated gene expression in PDAC cells. The.
AMPK induces VEGF-A production by upregulating ERK signaling.

AMPK induces VEGF-A production by upregulating ERK signaling.

Similar presentations

Ads by Google