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Androgen responses to adrenocorticotropic hormone infusion among individual women with polycystic ovary syndrome Kevin H. Maas, M.D., Ph.D., Sandy Chuan, M.D., Evan Harrison, M.D., Heidi Cook-Andersen, M.D., Ph.D., Antoni J. Duleba, M.D., R. Jeffrey Chang, M.D. Fertility and Sterility Volume 106, Issue 5, Pages (October 2016) DOI: /j.fertnstert Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions
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Figure 1 Mean (±SE) serum 17α-hydroxyprogesterone (17-OHP), dehydroepiandrosterone (DHEA), androstenedione (A), and testosterone (T) levels during 6-hour ACTH step-wise, dose-response infusion in women with polycystic ovary syndrome (PCOS) (filled circles) and healthy controls (open circles). ACTH doses: 0.1, 0.25, 1.0, 2.5, 10, and 25 μg/hr. Fertility and Sterility , DOI: ( /j.fertnstert ) Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions
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Figure 2 Correlation of hormone responses to ACTH infusion with 24-hour responses to recombinant hCG for dehydroepiandrosterone (DHEA) (upper panels), androstenedione (A) (middle panels), and 17α-hydroxyprogesterone (17-OHP) (lower panels) in individual control (left) and subjects with polycystic ovary syndrome (PCOS) (right). The response to ACTH was determined by area under the curve (Δ AUC) above baseline during the 6-hour infusion. The response to hCG was determined by the net change from baseline. In women with PCOS significant correlations were noted for DHEA (P=.04), A (P=.003), and 17-OHP (P=.03). Fertility and Sterility , DOI: ( /j.fertnstert ) Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions
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