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Increased apoptotic levels after combined treatment with vincristine (VCR) and imatinib.
Increased apoptotic levels after combined treatment with vincristine (VCR) and imatinib. A–D represent significant flow cytometry experiments analyzing Annexin-V-FITC detection. Histograms showing Annexin-V and propidium iodide distribution in presence of FBS (A), 10 μm imatinib (B), and imatinib with VCR (C) are shown in the top half of the figure. The number of A673 early apoptotic cells (Annexin-V +, propidium iodide −) increases when combined treatment was administered (50%) with respect to VCR alone (20%). D shows curve displacement of imatinib + VCR with respect to VCR alone. Iranzu González et al. Clin Cancer Res 2004;10: ©2004 by American Association for Cancer Research
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