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Increased apoptotic levels after combined treatment with DXR and imatinib.
Increased apoptotic levels after combined treatment with DXR and imatinib. A–D represent significant flow cytometry experiments analyzing Annexin-V-FITC detection. Histograms showing Annexin-V and propidium iodide distribution in presence of FBS (A), 10 μm imatinib (B), and imatinib with doxorubicin (DXR; C) are shown in the top half of the figure. The number of A673 early apoptotic cells (Annexin-V +, propidium iodide −) increased when combined treatment was administered (48%) with respect to DXR alone (33%). D shows curve displacement of imatinib + DXR with respect to DXR alone. Iranzu González et al. Clin Cancer Res 2004;10: ©2004 by American Association for Cancer Research
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