1. Steroid-resistant MCN
Steroid-resistant MCN. (A) Steroid-resistant MCN, shown here, resembles on light microscopy steroid-sensitive forms and normal kidney (Silver stain).
Steroid-resistant MCN. (A) Steroid-resistant MCN, shown here, resembles on light microscopy steroid-sensitive forms and normal kidney (Silver stain). (B) On electron microscopy, extensive foot process effacement is invariably seen, as well as podocyte microvillous transformation (cytoplasmic projections into the urinary space). (C) Podocin is expressed in normal kidney podocytes (immunofluorescence). (D) In a patient with steroid-resistant MCN, no staining for podocin was detected (immunofluorescence). Magnification, ×40 in A, C, and D; ×2500 in B.
Laura Barisoni et al. CJASN 2007;2:
©2007 by American Society of Nephrology