1. Histological evidence of the onset of knee OA in a rabbit model of botulinum toxin type-A induced muscle weakness (knee extensor muscles were weakened systematically to 20% of their original strength).
Histological evidence of the onset of knee OA in a rabbit model of botulinum toxin type-A induced muscle weakness (knee extensor muscles were weakened systematically to 20% of their original strength). Note the disruption of surface integrity, the loss of homogeneous staining and the disruption of cellular structure in the cartilage 4 weeks after the onset of muscle weakness (right panel) compared with a normal strength control animal (left panel). Similar results were also observed at 8 and 12 weeks post muscle weakness induction. OA, osteoarthritis.
Armaghan Mahmoudian et al. RMD Open 2018;4:e000468
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