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DNA methylation within melatonin receptor 1A (MTNR1A) mediates paternally transmitted genetic variant effect on asthma plus rhinitis  Chloé Sarnowski,

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Presentation on theme: "DNA methylation within melatonin receptor 1A (MTNR1A) mediates paternally transmitted genetic variant effect on asthma plus rhinitis  Chloé Sarnowski,"— Presentation transcript:

1 DNA methylation within melatonin receptor 1A (MTNR1A) mediates paternally transmitted genetic variant effect on asthma plus rhinitis  Chloé Sarnowski, PhD, Catherine Laprise, PhD, Giovanni Malerba, PhD, Miriam F. Moffatt, DPhil, Marie-Hélène Dizier, PhD, Andréanne Morin, MSc, Quentin B. Vincent, MD, PhD, Klaus Rohde, PhD, Jorge Esparza-Gordillo, PhD, Patricia Margaritte-Jeannin, PhD, Liming Liang, PhD, Young-Ae Lee, MD, Jean Bousquet, MD, Valérie Siroux, PhD, Pier Franco Pignatti, MD, William O. Cookson, MD, DPhil, Mark Lathrop, PhD, Tomi Pastinen, MD, Florence Demenais, MD, Emmanuelle Bouzigon, MD, PhD  Journal of Allergy and Clinical Immunology  Volume 138, Issue 3, Pages (September 2016) DOI: /j.jaci Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Genome-wide linkage scan conducted for AAR in European families with or without taking into account the POO effect (LOD maximum likelihood binomial method extended for imprinting [LOD-MLBI] or LOD maximum likelihood binomial method [LOD-MLB] curves, respectively). Genetic distance is plotted on the x-axis, and LOD score is plotted on the y-axis. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 Establishing the epigenetic mediation of genetic risk: CIT applied with the paternally inherited rs G allele as the causal factor (G), DNAm levels at cg as a potential mediator (M), and asthma plus rhinitis as the outcome (Y). Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig E1 Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Fig E2 Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

6 Fig E3 Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

7 Fig E4 Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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