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Kung-Yee Liang, Fang-Chi Hsu, Terri H. Beaty, Kathleen C. Barnes 

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1 Multipoint Linkage-Disequilibrium–Mapping Approach Based on the Case-Parent Trio Design 
Kung-Yee Liang, Fang-Chi Hsu, Terri H. Beaty, Kathleen C. Barnes  The American Journal of Human Genetics  Volume 68, Issue 4, Pages (April 2001) DOI: /319504 Copyright © 2001 The American Society of Human Genetics Terms and Conditions

2 Figure 1 Plots of E[Y(t)|ϕ] versus t, for 0≤t≤80 cM, where τ=45 cM and Pr[h(t)|h(τ)] is assumed to be equal to × |t-τ|. a, N=10 with different values of C=E[Y(τ)|ϕ]; b, C=.5 with different values of N. The American Journal of Human Genetics  , DOI: ( /319504) Copyright © 2001 The American Society of Human Genetics Terms and Conditions

3 Figure 2 Plots of E[Y(t)|ϕ] versus t, for 0≤t≤80 cM, where τ=45 cM and Pr[h(t)|h(τ)] is generated from a uniform distribution over (.5, 1.0). a, N=10 with different values of C; b, C=.5 with different values of N. The American Journal of Human Genetics  , DOI: ( /319504) Copyright © 2001 The American Society of Human Genetics Terms and Conditions

4 Figure 3 TDT values for the 22 markers on chromosome 12 from the family study of asthma (Barnes et al. 1996). The solid line (—) denotes the conventional TDT; the dashed line (- - -) denotes the modified TDT. The American Journal of Human Genetics  , DOI: ( /319504) Copyright © 2001 The American Society of Human Genetics Terms and Conditions

5 Figure 4 Number of allele transmissions from heterozygous parents, for the 22 markers on chromosome 12 from the family study of asthma (Barnes et al. 1996). The American Journal of Human Genetics  , DOI: ( /319504) Copyright © 2001 The American Society of Human Genetics Terms and Conditions

6 Figure 5 Empirical and fitted values for the expected preferential-transmission statistics for the 22 markers on chromosome 12 from the family study of asthma (Barnes et al. 1996). The solid line (—) denotes the empirical E(Y(t)|ϕ); the dashed line (- - -) denotes the empirical E[Y(t)|ϕ]/Pr[h(t)|h(τ)]; the dotted line (…) denotes the fitted E[Y(t)|ϕ]/Pr[h(t)|h(τ)]. The American Journal of Human Genetics  , DOI: ( /319504) Copyright © 2001 The American Society of Human Genetics Terms and Conditions

7 Figure 6 Estimated Pr[h(t)|h(τ)] for the 22 markers on chromosome 12 from the family study of asthma (Barnes et al. 1996) The American Journal of Human Genetics  , DOI: ( /319504) Copyright © 2001 The American Society of Human Genetics Terms and Conditions


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