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Hydroxyproline ingestion and urinary oxalate and glycolate excretion
J. Knight, J. Jiang, D.G. Assimos, R.P. Holmes Kidney International Volume 70, Issue 11, Pages (December 2006) DOI: /sj.ki Copyright © 2006 International Society of Nephrology Terms and Conditions
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Figure 1 Change in plasma hydroxyproline (inset), glycolate (▪), and oxalate (--▴--) after ingestion of 10g gelatin. Each time point represents the mean±s.e.m. *P<0.05 for the comparison of plasma glycolate or hydroxyproline at each post load collection time with the corresponding fasting value. Kidney International , DOI: ( /sj.ki ) Copyright © 2006 International Society of Nephrology Terms and Conditions
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Figure 2 Urinary glycolate (▪) and urinary oxalate (--▴--) following ingestion of 10g gelatin. Each collection represents the mean±s.e.m. *P<0.05 for the comparison of urinary glycolate or oxalate at each post load collection period with the corresponding fasting value. Kidney International , DOI: ( /sj.ki ) Copyright © 2006 International Society of Nephrology Terms and Conditions
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Figure 3 The ratio of glycolate clearance to creatinine clearance following 10g load of gelatin. Each collection represents the mean±s.e.m. Kidney International , DOI: ( /sj.ki ) Copyright © 2006 International Society of Nephrology Terms and Conditions
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Figure 4 Increases in urinary oxalate (▪) and glycolate (□) excretion over fasting levels in a 6-h period following ingestion of various loads of gelatin. Increases in urinary oxalate and glycolate excretion were calculated by subtracting three times the fasting 2h levels from the total amount measured in each collection. Plasma hydroxyproline (inset) was measured 3h after ingestion of each load. The asterisk denotes significantly higher (P<0.05) values compared to the 0g gelatin load. Each parameter represents the mean±s.e.m. Kidney International , DOI: ( /sj.ki ) Copyright © 2006 International Society of Nephrology Terms and Conditions
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Figure 5 Hydroxyproline transport and metabolism in hepatocytes. Hyp, trans-4-hydroxy-L-proline; GR, glyoxylate reductase; DAO, D-amino oxidase; AGT, alanine:glyoxylate aminotransferase; GO, glycolate oxidase; LDH, lactate dehydrogenase. Kidney International , DOI: ( /sj.ki ) Copyright © 2006 International Society of Nephrology Terms and Conditions
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Figure 6 Calibration curve for glycolate determination by ion chromatography coupled with electrospray mass spectrometry. Kidney International , DOI: ( /sj.ki ) Copyright © 2006 International Society of Nephrology Terms and Conditions
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