Presentation is loading. Please wait.

Presentation is loading. Please wait.

Fig. 1 Reaction rate, efficiency, and substrate scope of the thiol-to-amine macrocyclization reaction. Reaction rate, efficiency, and substrate scope of.

Published byAllen Cook Modified over 5 years ago

Similar presentations

Presentation on theme: "Fig. 1 Reaction rate, efficiency, and substrate scope of the thiol-to-amine macrocyclization reaction. Reaction rate, efficiency, and substrate scope of."— Presentation transcript:

1 Fig. 1 Reaction rate, efficiency, and substrate scope of the thiol-to-amine macrocyclization reaction. Reaction rate, efficiency, and substrate scope of the thiol-to-amine macrocyclization reaction. (A) Sample reaction of the dipeptide Gly-Cys and bis-electrophile linker 1. The higher thiol reactivity compared to amines enables stepwise reaction in the indicated order, forming a macrocycle as the main product with few side products. (B) Several bis-electrophiles efficiently cyclized the Gly-Cys substrate, adding between three and seven atoms to the macrocyclic backbone. (C to E) The substrate scope was assessed by quantifying the percent of linear substrate converted into the desired macrocycle. The N-terminal amino acid (C), the Cys side-chain length (D), and the number of amino acids were varied (E). R = Gly-Gly-Trp. S. S. Kale et al. Sci Adv 2019;5:eaaw2851 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

Download ppt "Fig. 1 Reaction rate, efficiency, and substrate scope of the thiol-to-amine macrocyclization reaction. Reaction rate, efficiency, and substrate scope of."

Similar presentations

Fig. 2 Chiral and achiral structures of formic acid.

Fig. 2 Chiral and achiral structures of formic acid.
Fig. 2 Transport properties of a BP transistor at low temperature.

Fig. 2 Transport properties of a BP transistor at low temperature.
Fig. 4 Ballistic simulation of BP FETs.

Fig. 4 Ballistic simulation of BP FETs.
Fig. 3 FM MnBi2Te4 bulk. FM MnBi2Te4 bulk. Crystal structure (A) and band structure (B) of the FM bulk. (C) Zoom-in band structures along the out-of-plane.

Fig. 3 FM MnBi2Te4 bulk. FM MnBi2Te4 bulk. Crystal structure (A) and band structure (B) of the FM bulk. (C) Zoom-in band structures along the out-of-plane.
Fig. 3 The electrical contact of direct-printed and reconfigured liquid metals. The electrical contact of direct-printed and reconfigured liquid metals.

Fig. 3 The electrical contact of direct-printed and reconfigured liquid metals. The electrical contact of direct-printed and reconfigured liquid metals.
Fig. 2 Global production, use, and fate of polymer resins, synthetic fibers, and additives (1950 to 2015; in million metric tons). Global production, use,

Fig. 2 Global production, use, and fate of polymer resins, synthetic fibers, and additives (1950 to 2015; in million metric tons). Global production, use,
Fig. 4 INS spectra of different human bones from the Roman period [humerus, ulna, femur, and fibula from the same skeleton, Guidonia-Montecelio, Italy.

Fig. 4 INS spectra of different human bones from the Roman period [humerus, ulna, femur, and fibula from the same skeleton, Guidonia-Montecelio, Italy.
Fig. 2 CFD results. CFD results. Results of CFD simulations in horizontal (left column) and vertical (right column) cross-sections. All models oriented.

Fig. 2 CFD results. CFD results. Results of CFD simulations in horizontal (left column) and vertical (right column) cross-sections. All models oriented.
Fig. 3 Vibrational spectra of human bones from the Copper Age (Scoglietto cave, Italy). Vibrational spectra of human bones from the Copper Age (Scoglietto.

Fig. 3 Vibrational spectra of human bones from the Copper Age (Scoglietto cave, Italy). Vibrational spectra of human bones from the Copper Age (Scoglietto.
Vibrational spectra of medieval human bones (Leopoli-Cencelle, Italy)

Vibrational spectra of medieval human bones (Leopoli-Cencelle, Italy)
Fig. 5 Thermal conductivity of n-type ZrCoBi-based half-Heuslers.

Fig. 5 Thermal conductivity of n-type ZrCoBi-based half-Heuslers.
Fig. 1 Map of water stress and shale plays.

Fig. 1 Map of water stress and shale plays.
Fig. 1 Examples of experimental stimuli and behavioral performance.

Fig. 1 Examples of experimental stimuli and behavioral performance.
Fig. 3 Electron PSD in various regions.

Fig. 3 Electron PSD in various regions.
Fig. 4 Complete separation of water and solute after stable and efficient solar evaporation. Complete separation of water and solute after stable and efficient.

Fig. 4 Complete separation of water and solute after stable and efficient solar evaporation. Complete separation of water and solute after stable and efficient.
Fig. 2 Some examples of weekly forecasts (the number of the forecasts are reported on Table 1). Some examples of weekly forecasts (the number of the forecasts.

Fig. 2 Some examples of weekly forecasts (the number of the forecasts are reported on Table 1). Some examples of weekly forecasts (the number of the forecasts.
Fig. 4 Resynthesized complex boronic acid derivatives based on different scaffolds on a millimole scale and corresponding yields. Resynthesized complex.

Fig. 4 Resynthesized complex boronic acid derivatives based on different scaffolds on a millimole scale and corresponding yields. Resynthesized complex.
Fig. 1 Importance of boronic acids, commonly used synthetic methods for the ─B(OH)2 introduction, and our proposed building block–centered approach. Importance.

Fig. 1 Importance of boronic acids, commonly used synthetic methods for the ─B(OH)2 introduction, and our proposed building block–centered approach. Importance.
HT Suzuki reaction of boronic acids using the building block approach

HT Suzuki reaction of boronic acids using the building block approach
HT synthesis of boronic acids using the building block approach

HT synthesis of boronic acids using the building block approach

Similar presentations

Ads by Google