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Monocyte chemotactic protein (MCP3) promoter polymorphism is associated with atopic asthma in the Indian population  Jyotsna Batra, PhD, Sudipta Das,

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Presentation on theme: "Monocyte chemotactic protein (MCP3) promoter polymorphism is associated with atopic asthma in the Indian population  Jyotsna Batra, PhD, Sudipta Das,"— Presentation transcript:

1 Monocyte chemotactic protein (MCP3) promoter polymorphism is associated with atopic asthma in the Indian population  Jyotsna Batra, PhD, Sudipta Das, MSc, Rajshekhar Chatterjee, PhD, Sunandini Chandra, MSc, Balaram Ghosh, PhD  Journal of Allergy and Clinical Immunology  Volume 128, Issue 1, Pages e3 (July 2011) DOI: /j.jaci Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 A, Analysis of differential binding of nuclear proteins to C and T alleles of the MCP3−1382T/C polymorphism by using the electrophoretic mobility shift assay. Lanes 1 and 12 represent free probe. Lanes 2, 3, and 13 represent complexes with T/C probe. Lanes 4 to 6 and 7 to 11 represent competition assays. Lanes 14 to 17 represent supershift assays. CEBP, CCAAT enhancer-binding protein; ETS, erythroblast transformation specific; PBX, pre B-cell leukemia transcription factor; YY-1, Ying-Yang 1. B, Relative transcriptional activities forMCP3−1382T/C reporter constructs measured by using transient transfection assays. The figure represents data from 3 independent experiments. Journal of Allergy and Clinical Immunology  , e3DOI: ( /j.jaci ) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 A, Schematic representation of the MCP1-MCP3 gene cluster on chromosome 17q21.2. The SNPs and microsatellite repeat (M1) studied in our population are marked in boldface. B, Pairwise LD for 2-way comparisons among the polymorphisms investigated in the MCP3 gene, as calculated with EMLD software. Journal of Allergy and Clinical Immunology  , e3DOI: ( /j.jaci ) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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