1. (A–F) Changes of B-cell numbers and B-cell related biomarkers.
(A–F) Changes of B-cell numbers and B-cell related biomarkers. Total number of B cells (Log10 109/L; A), serum IgA rheumatoid factor (RF) (Log kU/L; B), IgM-RF (Log kU/L; C), IgG-RF (Log kU/L; D); IgM (Log g/L; E), and anti-citrullinated cyclic peptide (CCP) test levels (Log kAU/L; F) from baseline to follow-up time points (days) measured in the individuals treated with placebo (red) and rituximab (green). The thin lines represent changes in the individuals and the thick lines represent the mean numbers/levels for each group. Vertical lines represent the 95% CIs. Statistically significant differences (shown p values) between the two treatment groups were found for all values depicted here, except for the serum IgG-RF and anti-CCP levels.
Danielle M Gerlag et al. Ann Rheum Dis 2019;78:
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