1. Myocardial tissue CO2 tension detects coronary blood flow reduction after coronary artery bypass in real-time† 
S.E. Pischke, S. Hyler, C. Tronstad, J. Bergsland, E. Fosse, P.S. Halvorsen, H. Skulstad, T.I. Tønnessen 
British Journal of Anaesthesia 
Volume 114, Issue 3, Pages (March 2015)
DOI: /bja/aeu381
Copyright © 2015 The Author(s) Terms and Conditions

2. Fig 1
Blood flow in the LIMA graft was reliably reduced from baseline levels (100%) to 75, 50 and 25% (lowest panel). Myocardial P t C O 2 increased significantly (*) and flow-dependently during all blood flow reduction events. Maximum P t C O 2 during 25% blood flow was significantly different from the two other occlusion intervals (#). Myocardial pH was significantly reduced during every blood flow reduction event (‡) and was significantly more reduced during 25% blood flow when compared with 50 and 75% blood flow (#). Myocardial P t O 2 decreased significantly during every blood flow reduction (†) and reached zero during 50 and 25% blood flow. All values expressed as median (pink lines) and quartile range (blue area); P≤0.05, exact values presented in text.
British Journal of Anaesthesia  , DOI: ( /bja/aeu381)
Copyright © 2015 The Author(s) Terms and Conditions

3. Fig 2
(a) Myocardial tissue microdialysis showed significant and flow-dependent increase of lactate in the LIMA graft-dependent region (blue bars) in comparison with baseline (*) and to the Cx-dependent control area (green bars, #) when LIMA graft blood flow was reduced. (b) Tissue glucose was region specific reduced during every LIMA graft blood flow reduction with significance during 50 and 25%. (c) Myocardial glycerol increased significantly and flow-dependently in the LIMA graft-dependent region only. All values presented as mean (sd); *, #: P≤0.05, exact values presented in text.
British Journal of Anaesthesia  , DOI: ( /bja/aeu381)
Copyright © 2015 The Author(s) Terms and Conditions

4. Fig 3
Regional cardiac function assessed as radial strain showed significant and flow-dependent decrease in the LIMA graft-dependent region (blue bars) in comparison with baseline (*) and to the Cx-dependent control area (green bars, #) when LIMA graft blood flow was reduced. All values presented as mean (sd); *, #: P≤0.05, exact values presented in text.
British Journal of Anaesthesia  , DOI: ( /bja/aeu381)
Copyright © 2015 The Author(s) Terms and Conditions

5. Fig 4
Pearson correlation revealed significant correlation in the LIMA graft-dependent region between myocardial P t C O 2 and regional cardiac function measured as radial strain (a), tissue lactate (b), and tissue pH (c). Single values displayed as baseline (squares), LIMA blood flow 75% (open triangles), 50% (filled triangles), and 25% (diamonds).
British Journal of Anaesthesia  , DOI: ( /bja/aeu381)
Copyright © 2015 The Author(s) Terms and Conditions

6. Fig 5
P t C O 2 measured by a total of 10 conductometric IscAlert sensors was obtained in 3 animals. During intervals of LIMA graft blood flow reduction, P t C O 2 increased flow-dependently in the LIMA graft-dependent region (blue), while it was unaffected in the Cx control region (green). All values expressed as median (continuous lines) and quartile range (dashed line).
British Journal of Anaesthesia  , DOI: ( /bja/aeu381)
Copyright © 2015 The Author(s) Terms and Conditions