1. The Critical Role of Non-catalytic Cysteine Residues in Proteins
Jean Bertoldo 
Chem 
Volume 3, Issue 4, Pages (October 2017)
DOI: /j.chempr
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2. Figure 1
Schematics of the Proposed Water-Bridged Cysteine-Cysteine Redox Regulation Mechanism in Protein Tyrosine Phosphatases
Cysteine phosphatases (A) can prevent catalytic overoxidation (C) by forming a disulfide bridge with a backdoor non-catalytic cysteine in close proximity (B) and thus becoming reversibly inactivated. Non-catalytic cysteines (D) act synergistically as oxidative scavengers while a water-bridged motif consisting of a catalytic cysteine and a backdoor cysteine protects the catalytic pocket, allowing the enzyme to remain active under stress conditions.
Chem 2017 3, DOI: ( /j.chempr )
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3. Chem 2017 3, DOI: ( /j.chempr )
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