1. Identification of general and tissue-specific essential genes.
Identification of general and tissue-specific essential genes. A, representation of selection criteria underlying definition of the 297 general essential genes. The histogram at right shows the number of cell lines in which each gene is found essential. The “Wordle” (inset) depicts the most frequently occurring KEGG pathways among the general essential genes, in which the most frequently occurring terms are illustrated in larger type. B, heat map of differentially essential genes in the 3 tumor types. Here, 155 genes were identified as specific to breast cell lines, 66 to ovarian cell lines, and 187 to pancreatic cell lines. The complete list of genes is available in Supplementary Table S8. C, range of zGARP scores for 6 tissue-specific genes. P values comparing the range of scores were determined using the Kruskal-Wallis test.
Richard Marcotte et al. Cancer Discovery 2012;2:
©2012 by American Association for Cancer Research