1. Frequently mutated genes in colorectal cancer.
Frequently mutated genes in colorectal cancer. Mutation landscape showing the subtypes of the 592 TCGA tumor samples, sorted by increasing mutation load, including MSI status, POLE status, and Lynch status. Samples reported on previously by TCGA (2012) are indicated. Molecular subtypes (see Methods) enriched in MSI-high or MSS are indicated: *, P < 0.01; **, P < 1.0 × 10−4; ***, P < 1.0 × 10−6. Consensus Molecular Subtypes (CMS) are shown; MSI-high is enriched for CMS1, the microsatellite instability immune subset (P < 1 × 10−15). Mutations defining genomic subtypes are in Methods.
Catherine S. Grasso et al. Cancer Discov 2018;8:
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