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Prediction of Area under the Cyclosporine Concentration Versus Time Curve in Children Undergoing Hematopoietic Stem Cell Transplantation  L. Lee Dupuis,

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Presentation on theme: "Prediction of Area under the Cyclosporine Concentration Versus Time Curve in Children Undergoing Hematopoietic Stem Cell Transplantation  L. Lee Dupuis,"— Presentation transcript:

1 Prediction of Area under the Cyclosporine Concentration Versus Time Curve in Children Undergoing Hematopoietic Stem Cell Transplantation  L. Lee Dupuis, Winnie Seto, Oliver Teuffel, Paul Gibson, Kirk R. Schultz, John D. Doyle, Adam Gassas, R. Maarten Egeler, Lillian Sung, Tal Schechter  Biology of Blood and Marrow Transplantation  Volume 19, Issue 3, Pages (March 2013) DOI: /j.bbmt Copyright © 2013 American Society for Blood and Marrow Transplantation Terms and Conditions

2 Figure 1 Bland-Altman plots. Percent difference against mean for actual (AUC-12) and predicted area under the whole blood cyclosporine concentration versus time curve during 12-hour dosing interval generated by LSS. Percent difference = 100 × [(AUC-12–AUC predicted by LSS)]/mean of AUC-12 and AUC predicted by LSS]. (A) First-dose 4-point LSS validation: % difference against mean AUC. (B) Steady-state 3-point LSS development: % difference against mean AUC. (C) Steady-state three-point LSS validation: % difference against mean AUC. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2013 American Society for Blood and Marrow Transplantation Terms and Conditions


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