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Published byKristina Pavlíková Modified over 5 years ago
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Effects of in vivo myocardial ischemia and reperfusion on interstitial nitric oxide metabolites
Randy M Stevens, MD, M.Salik Jahania, MD, Jennifer E Stivers, BS, Robert M Mentzer, MD, Robert D Lasley, PhD The Annals of Thoracic Surgery Volume 73, Issue 4, Pages (April 2002) DOI: /S (02)
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Fig 1 Dialysate nitric oxide (NO) metabolite concentration (NOx) in the left anterior descending (LAD) artery and left circumflex (LCX) coronary artery beds during 15 minutes of LAD occlusion (ISCH) and 2 hours reperfusion. Values are expressed as percent change from preischemic (PreISCH) baseline. ∗p < 0.05 versus baseline. The Annals of Thoracic Surgery , DOI: ( /S (02) )
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Fig 2 Dialysate nitric oxide (NO) metabolite concentrations (NOx) in the midmyocardium during 60 minutes of ischemia and 2 hours reperfusion. Values are expressed as percent change from baseline (time 0). Dialysate left circumflex (LCX) coronary artery values during left anterior descending (LAD) artery occlusion were not significantly different from baseline. ∗p < 0.05 versus baseline. (PreISCH = preischemic.) The Annals of Thoracic Surgery , DOI: ( /S (02) )
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Fig 3 The effects of ischemic preconditioning on dialysate (NOx). Preconditioning was induced by two cycles of 5 minutes of ischemia ([ISCH] gray bars) and 10 minutes of reperfusion ([RP] black bars). Values are expressed as percent change from preischemic (PreISCH) baseline. ∗p < 0.05 versus baseline. The Annals of Thoracic Surgery , DOI: ( /S (02) )
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Fig 4 Dialysate (NOx) during (A) prolonged ischemia and (B) ischemia and reperfusion in 60-minute ischemia alone (60′ Isch alone) and ischemic preconditioned (IPC) pigs. All ischemic NOx values (A) were significantly different from respective preischemic (PreISCH) baseline values (p < 0.05) but symbols were not shown for clarity. ∗p < 0.05 versus control group value; #p < 0.05 versus respective PreISCH value. (LAD = left anterior descending artery.) The Annals of Thoracic Surgery , DOI: ( /S (02) )
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