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Biological Functions of Activity-Dependent Transcription Revealed

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Presentation on theme: "Biological Functions of Activity-Dependent Transcription Revealed"— Presentation transcript:

1 Biological Functions of Activity-Dependent Transcription Revealed
Anne E. West  Neuron  Volume 60, Issue 4, Pages (November 2008) DOI: /j.neuron Copyright © 2008 Elsevier Inc. Terms and Conditions

2 Figure 1 Schematic for the Role of Activity-Dependent Bdnf Transcription in the Regulation of GABAergic Synapses (1) Excitatory synaptic activity (Glu) leads to the activation of intracellular calcium signaling cascades. (2) In the nucleus, calcium-activated kinases phosphorylate CREB and modulate additional transcriptional regulators bound to three calcium-response elements (CaREs) in the proximal region of Bdnf promoter IV. (3) Transcription of Bdnf exon IV is initiated, and newly synthesized BDNF protein is translated and packaged for secretion. (4) Secreted BDNF increases the number of GABAergic synapses. Neuron  , DOI: ( /j.neuron ) Copyright © 2008 Elsevier Inc. Terms and Conditions

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