1. HYPOTHYROIDISM

2. INTRODUCTION
Hypothyroidism is defined as a deficiency in thyroid hormone secretion and action that produces a variety of clinical signs and symptoms of Hypometabolism.
Overt Hypothyroidism is defined as an elevated serum TSH concentration (usually above 10 mIU/L) and reduced free Thyroxine concentration (fT4)
Subclinical Hypothyroidism is defined as serum TSH above the upper reference limit in combination with a normal free Thyroxine (fT4)

3. Prevalence
According to a projection from various studies on Thyroid disease, it has been estimated that about 42 million people in India suffer from Thyroid diseases. The prevalence of Hypothyroidism was 3.9%. The prevalence of subclinical Hypothyroidism was 9.4%. In women, the prevalence was higher, at 11.4%, when compared with men, in whom the prevalence was 6.2%. The prevalence of subclinical Hypothyroidism increased with age. About 53% of subjects with subclinical hypothyroidism were positive for anti- TPO antibodies.

4. CLINICAL PRESENTATION
Hypothyroidism can affect all organ systems & these manifestations are largely independent of the underlying disorder but are a function of the degree of hormone deficiency.

6. CAUSES OF HYPOTHYROIDISM

7. Interesting, right?
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