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Of Mice and Man: Differential DNMT Dependence in Mammalian ESCs

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1 Of Mice and Man: Differential DNMT Dependence in Mammalian ESCs
Ozren Bogdanović, Ryan Lister  Cell Stem Cell  Volume 16, Issue 5, Pages (May 2015) DOI: /j.stem Copyright © 2015 Elsevier Inc. Terms and Conditions

2 Figure 1 Differentiation Potential of hESC DNMT Mutant Lines
DNMT1 is essential for hESC viability, and disruption of DNMT1 in hESCs causes immediate cell death. Both DNMT3A and DNMT3B are dispensable for hESC maintenance and differentiation as exemplified by embryoid body (EB) and teratoma formation in DNMT3A−/−, DNMT3B−/−, and DNMT3A−/−; DNMT3B−/− mutant lines. Cell Stem Cell  , DOI: ( /j.stem ) Copyright © 2015 Elsevier Inc. Terms and Conditions

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