1. Imaging inflammation and tumor-associated lymphangiogenesis.
Imaging inflammation and tumor-associated lymphangiogenesis. A, schematic representation of the Vegfr3EGFPluc reporter knocked in downstream of the endogenous Vegfr3 locus, which uses an IRES for monitoring VEGFR3 expression. B, DMBA/TPA-induced skin papillomas in Vegfr3EGFPluc/+ reporter mice displayed localized lymphangiogenesis as indicated by the black arrows. C, whole body imaging of tumor-activated lymphangiogenesis over time in a B16-V5 melanoma xenograft model at distant lymph nodes (red arrows) before metastasis of the primary tumor xenograft in female Vegfr3EGFPluc/+ reporter mice. Images from Martinez-Corral and colleagues (51) modified and reprinted with permission from Proceedings of the National Academy of Sciences of the United States of America.
Brandon Kocher, and David Piwnica-Worms Cancer Discovery 2013;3:
©2013 by American Association for Cancer Research