1. Global mutational landscape of the 170 lung adenocarcinoma patients (discovery cohort).
Global mutational landscape of the 170 lung adenocarcinoma patients (discovery cohort). A, clinical data (mutation count, sex, smoking status, and subtype) and types of mutation for the 22 genes that were significantly mutated and expressed in lung adenocarcinoma. Mutation color code: dark blue, missense mutation; red, nonsense substitution; green, splice-site mutation; light blue, frame-preserving small indel; orange, frame-shifting small indel. Subtype color code: dark blue, acinar; light blue, papillary; red, solid; orange, micropapillary; green, mucinous. B, global pattern of CNV amplification (red) and deletion (blue). The amplitude of CNV amplification or deletion was determined using the G-score obtained by GISTIC (26). The chromosomal loci and representative genes of the 13 significantly altered CNVs are indicated on top (amplification) and bottom (deletion) of the panel (see Supplementary Table S7 and Supplementary Methods). The q value cutoff of 0.01 is indicated by the green lines.
Seongmin Choi et al. Clin Cancer Res 2015;21:
©2015 by American Association for Cancer Research