1. NIX loss delays cancer progression in KRAS-driven models of PDAC
NIX loss delays cancer progression in KRAS-driven models of PDAC. A, Representative images of hematoxylin and eosin (H&E) staining of the pancreata in 9- to 12-month-old KC and KCNixΔ/Δ mice, 1.5× magnification.
NIX loss delays cancer progression in KRAS-driven models of PDAC. A, Representative images of hematoxylin and eosin (H&E) staining of the pancreata in 9- to 12-month-old KC and KCNixΔ/Δ mice, 1.5× magnification. Inset image: 20× magnification. Scale bars, 200 μm. n = 5 mice per genotype. B, Quantification of the fraction of normal pancreas remaining in 9- to 12-month-old KC and KCNixΔ/Δ mice. n = 5 mice per genotype. Unpaired two-tailed t test. C, Representative images of H&E staining of the lesions found in 9- to 12-month-old KC and KCNixΔ/Δ mice. n = 5 mice per genotype. Scale bars, 100 μm. D, Classification of highest-grade PanIN lesions present in 9- to 12-month-old KC and KCNixΔ/Δ mice. n = 5 mice per genotype. E, Representative images of H&E staining of the lesions found in 4-month-old KPC and KPCNixΔ/Δ mice. n = 5 mice per genotype. Scale bars, 100 μm. F, Classification of highest-grade lesions present in 4-month-old KPC and KPCNixΔ/Δ mice. n = 5 mice per genotype. CPN, cystic papillary neoplasm. *, P < 0.05.
Timothy J. Humpton et al. Cancer Discov 2019;9:
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