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Genetic Variants in CTLA4 Are Strongly Associated with Alopecia Areata

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Presentation on theme: "Genetic Variants in CTLA4 Are Strongly Associated with Alopecia Areata"— Presentation transcript:

1 Genetic Variants in CTLA4 Are Strongly Associated with Alopecia Areata
Karsten K-G John, Felix F. Brockschmidt, Silke Redler, Christine Herold, Sandra Hanneken, Sibylle Eigelshoven, Kathrin A. Giehl, Jozef De Weert, Gerhard Lutz, Roland Kruse, Hans Wolff, Bettina Blaumeiser, Markus Böhm, Tim Becker, Markus M. Nöthen, Regina C. Betz  Journal of Investigative Dermatology  Volume 131, Issue 5, Pages (May 2011) DOI: /jid Copyright © 2011 The Society for Investigative Dermatology, Inc Terms and Conditions

2 Figure 1 Details of the investigated genomic region ( – bp; NCBI reference sequence build 36) on chromosome 2. (a) Transcript information for the investigated cytotoxic T lymphocyte antigen-4 (CTLA4) locus (UCSC Genome Browser, build 36), with arrows indicating the direction of transcription. (b) Negative log10 association P-values of markers analyzed in the case–control study. (c) Linkage disequilibrium (LD) at the CTLA4 locus is displayed by r2. LD and haplotype blocks were analyzed using Haploview software (version 4.1). Journal of Investigative Dermatology  , DOI: ( /jid ) Copyright © 2011 The Society for Investigative Dermatology, Inc Terms and Conditions


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