1. Pemetrexed (Pmx) nephrotoxicity may result from proximal tubular cell uptake of drug through apical (folate receptor-α [FR-α]) and basolateral (reduced folate carrier [RFC]) transporters.
Pemetrexed (Pmx) nephrotoxicity may result from proximal tubular cell uptake of drug through apical (folate receptor-α [FR-α]) and basolateral (reduced folate carrier [RFC]) transporters. After it is inside the cell, Pmx is polyglutamylated, which inhibits drug transport out of the cell and enhances drug inhibition of folate metabolism. Impaired synthesis of RNA and DNA by cells causes clinical AKI and tubulopathy. Pmx-glt, polyglutamylated pemetrexed.
Mark A. Perazella CJASN 2012;7:
©2012 by American Society of Nephrology