1. Multiple Curricula for B Cell Developmental Programming
Ellen V. Rothenberg 
Immunity 
Volume 45, Issue 3, Pages (September 2016)
DOI: /j.immuni
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2. Figure 1 Distinct Cohorts of B-1 and B-2 B Cell Precursors
This figure depicts three B-1 B cell precursor types (B-1p—I, —II, —III) and two B-2 B cell precursor types (B-2p—II, —III) according to the developmental age at which they emerge. Top shows early fetal stages. Middle shows late fetal and perinatal stages. Bottom shows adult postnatal stages. Teal color in “nuclei” indicates lin28b expression, with higher levels indicated by darker color. True definitive stem cells are indicated with blue outlines. The earliest dedicated B-1 B cell precursors (B-1p—I), distinguished by their PU.1-enhancer dependence (magenta arrows), are probably specified before definitive stem cells have been generated, from either yolk sac or early fetal liver hematopoietic progenitors. Later, adult B-2p—III are also acutely dependent on the PU.1 enhancer. These generate most B-2 cells in adult mice. Note that at all stages, the levels of EBF1 and Pax5 are higher in the B-1p (yellow-green gradient outline) than in B-2p (blue-violet gradient outline).
Immunity  , DOI: ( /j.immuni )
Copyright © 2016 Elsevier Inc. Terms and Conditions