1. Looking at periodicity in protein sequence and structure

2. The enzyme adenylosuccinate lyase

3. The enzyme adenylosuccinate lyase

4. The enzyme adenylosuccinate lyase
Sequence of one of the surface helices: LLIRRALAAVKEKARAVGDQLASM
Is this sequence amphipathic when examined in an a-helical configuration?

5. The enzyme adenylosuccinate lyase
LLIRRALAAVKEKARAVGDQLASM
LLIRQAISLVKEKAKAVGEELTRL
LLVRRALGHIKRKVNAVGGELASL
LLIRRALSIIKKKINAAGEELARL
LLIRRALSIVKRKLDIAGEELKRL
IIVKKALEIVKKKLRDVITILIEY
LVFRDAIRLVKTKVVEILEMMVSL
LIFRDAIRLVKRKIMEILEIMISL
LIIRDALAKVYKDLKEIIKKFLEI
LVLREALSIIYRRLHRLAEVLAEK
Number of different amino acids types at the given position
In a multiple sequence alignment, does the degree of sequence variation at different positions reflect a potential alpha helical character?

6. The enzyme adenylosiccinate lyase
LLIRRALAAVKEKARAVGDQLASM
LLIRQAISLVKEKAKAVGEELTRL
LLVRRALGHIKRKVNAVGGELASL
LLIRRALSIIKKKINAAGEELARL
LLIRRALSIVKRKLDIAGEELKRL
IIVKKALEIVKKKLRDVITILIEY
LVFRDAIRLVKTKVVEILEMMVSL
LIFRDAIRLVKRKIMEILEIMISL
LIIRDALAKVYKDLKEIIKKFLEI
LVLREALSIIYRRLHRLAEVLAEK
Number of different amino acids types at the given position
In a multiple sequence alignment, does the degree of sequence variation at different positions reflect a potential alpha helical character?

7. The enzyme adenylosuccinate lyase
Number of different amino acids types at the given position
In a multiple sequence alignment, does the degree of sequence variation at different positions reflect a potential alpha helical character?

8. The enzyme adenylosuccinate lyase
Number of different amino acids types at the given position
In a multiple sequence alignment, does the degree of sequence variation at different positions reflect a potential alpha helical character?

9. Porin: a transmembrane beta barrel
Residues : GLN TRP ALA THR GLY LEU LYS TYR ASP ALA

10. Porin: a transmembrane beta barrel
Inside surface: aqueous
Outside surface: lipid-facing
Residues : GLN TRP ALA THR GLY LEU LYS TYR ASP ALA