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Retrograde Coronary Perfusion: Effects on Iatrogenic Edema and Diastolic Properties  David A Dean, Chao-Xiang Jia, Santos E Cabreriza, Pablo F Soto, David.

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Presentation on theme: "Retrograde Coronary Perfusion: Effects on Iatrogenic Edema and Diastolic Properties  David A Dean, Chao-Xiang Jia, Santos E Cabreriza, Pablo F Soto, David."— Presentation transcript:

1 Retrograde Coronary Perfusion: Effects on Iatrogenic Edema and Diastolic Properties 
David A Dean, Chao-Xiang Jia, Santos E Cabreriza, Pablo F Soto, David G Rabkin, Michael J Sardo, Natalya Chalik, Henry M Spotnitz  The Annals of Thoracic Surgery  Volume 65, Issue 2, Pages (February 1998) DOI: /S (97)

2 Fig. 1 Effects of antegrade and retrograde perfusion on pressure–volume relationship in isolated arrested left ventricle (LV). Pressure and normalized volume were averaged for data grouped into pressure intervals averaging 0, 5, 10, 15, and 20 mm Hg (see text). An additional data point was obtained by averaging pressure at zero volume. With antegrade perfusion, filling volume after (Post) perfusion was significantly lower at pressures averaging 10, 15, and 20 mm Hg. Standard errors are indicated by brackets. (Pre = before.) The Annals of Thoracic Surgery  , DOI: ( /S (97) )

3 Fig. 2 Relation between perfusate dilution and change in heart weight (HW) after perfusion. Change in HW increased linearly with hemodilution after antegrade perfusion, whereas no effect of osmolarity on HW was observed after retrograde perfusion. The difference between the antegrade and retrograde groups is significant by analysis of covariance. The Annals of Thoracic Surgery  , DOI: ( /S (97) )

4 Fig. 3 Relation between perfusate dilution and change in filling volume at 15 mm Hg filling pressure (LVV-15). Changes in LVV-15 after antegrade perfusion were directly related to perfusate hemodilution, but no effect of osmolarity on LVV-15 was observed after retrograde perfusion. The difference between the antegrade and retrograde groups is significant by analysis of covariance. The Annals of Thoracic Surgery  , DOI: ( /S (97) )

5 Fig. 4 Relation between change in heart weight and change in filling volume at 15 mm Hg filling pressure (LVV-15) for all animals in study. Heart weight was closely related to changes in compliance (correlation coefficient = 0.93). This relation did not appear to be affected by type of perfusion, either retrograde or antegrade. (LV = left ventricle; WHW = wet heart weight.) The Annals of Thoracic Surgery  , DOI: ( /S (97) )


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