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Accessories to Limb Regeneration

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Presentation on theme: "Accessories to Limb Regeneration"— Presentation transcript:

1 Accessories to Limb Regeneration
Yanchao Han, Kenneth D. Poss  Developmental Cell  Volume 37, Issue 4, Pages (May 2016) DOI: /j.devcel Copyright © 2016 Elsevier Inc. Terms and Conditions

2 Figure 1 A Model of Salamander Accessory Limb Formation
The formation of an accessory limb requires three components: a lateral wound in the upper limb, a nerve deviated to the wound, and a skin graft from the opposite (in this case, posterior) side. Nerve deviation converts skin wound healing to blastema formation, whereas juxtaposition of anterior and posterior tissues provides positional information for blastemal patterning and outgrowth of an accessory limb. Nerve-derived BMP/FGF signals, anterior FGF signal, and posterior SHH signal are required in these processes. Artwork by A. Dickson. Developmental Cell  , DOI: ( /j.devcel ) Copyright © 2016 Elsevier Inc. Terms and Conditions

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